Preparatory Mindset

MODS is the PROGRESSIVE dysfunction of ≥2 organ systems in an acutely ill patient, usually from SIRS/sepsis. The lungs are typically the FIRST organ affected (ARDS). MODS carries a high mortality (40-80%). Treatment is supportive — there is no specific therapy. Prevention (early resuscitation, source control) is critical.

Core Concepts

• MODS = progressive dysfunction of ≥2 organ systems due to severe illness (usually SIRS/sepsis).


• Sequential organ failure: lungs (ARDS) → liver → kidney → GI → coagulation → CNS.


• Pathophysiology: uncontrolled inflammation → endothelial damage → capillary leak → microvascular thrombosis → organ hypoperfusion.


• SIRS criteria (≥2 of): temp >38°C or <36°C, HR >90, RR >20 or PaCO₂ <32, WBC >12K or <4K or >10% bands.


• Mortality: 40-80%, increases with number of organs failing.


• Treatment: supportive — treat underlying infection, maintain organ perfusion, prevent complications..

High-Yield Points

• ≥2 organs failing in acute illness


• Most commonly: lungs (ARDS) → liver → kidney → GI → coagulation


• Mortality increases with number of organs involved


• SIRS criteria: temp, HR, RR, WBC


• qSOFA: altered mental status, RR ≥22, SBP ≤100

Topic Summary

MODS is progressive dysfunction of ≥2 organs from SIRS/sepsis. The lungs are usually first affected. Mortality is high; treatment is supportive.